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Diclofenac and prednisone -

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Diclofenac and prednisone.



  It was determined that the combination of a single dose of prednisolone and diclofenac is well-suited to the treatment of postoperative pain, trismus. The combination of diclofenac and prednisolone has a better analgesic and anti-inflammatory effect. ❿  


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However, few studies have evaluated the activity of the combined effects of these two drugs. The purpose of this study was to evaluate whether a single dose of prednisolone, taken orally before operation, would increase the effects of diclofenac in preventing pain and swelling after surgical removal of impacted third molars. Methods: Thirty healthy patients requiring surgical removal of four third molars were randomly assigned to two groups.

In group A, patients were preoperatively given 50 mg of either diclofenac or placebo when impacted teeth were removed on each side. In group B, in addition to 50 mg of diclofenac, 10 mg of prednisolone or placebo was administered. In the second group, each patient was given 25 mg prednisolone and diclofenac intramuscularly immediately after surgery, and in the third group, each patient was given sterile saline solution as control group.

Postoperative pain was evaluated by visual analogue scale on the day of surgery. Facial swelling and trismus were evaluated on postoperative days 2 and 7. ANOVA was used to analyze these data. Conclusion: It was determined that the combination of a single dose of prednisolone and diclofenac is well-suited to the treatment of postoperative pain, trismus, and swelling after dental surgical procedures and should be used when extensive postoperative swelling of soft tissue is anticipated.

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Diclofenac and prednisone -



    Publication types Randomized Controlled Trial. Patients who are unable to provide informed consent. Sin , , 32 6 , Hide glossary Glossary Study record managers: refer to the Data Element Definitions if submitting registration or results information.

Recruitment status was: Not yet recruiting First Posted : October 30, Last Update Posted : October 30, View this study on Beta.

Study Description. To assess the effect of using diclofenac potassium versus prednisolone as a pre-medication compared to placebo on: Intensity of post-endodontic pain in patients with symptomatic irreversible pulpitis. Pulpal IL-8 expression. Incidence of post-endodontic pain in patients with symptomatic irreversible pulpitis.

Show detailed description. Hide detailed description. Detailed Description:. Patients will be asked to rate their pre-operative pain intensity ie, before the commencement of any treatment [baseline score]; on the visual analogue scale "VAS" Enrolled patients will be randomly assigned into one of three groups: Intervention Group 1 Diclofenac Potassium : single, oral dose of 50 mg diclofenac potassium pre-medication Cataflam; NOVARTIS Pharma, Basel, Switzerland one hour before starting endodontic treatment.

After anesthesia is achieved and verified with Endo-Ice, the patient's tooth is isolated with a rubber dam, caries is excavated, and the pulp is exposed with a sterile round bur. Preparation of access cavity using a sterile round carbide bur and an Endo-Z bur Sample Collection: Blood from the exposed surface of the pulp will be collected with 2 sterile cotton pellets.

The pellets will be held at the exposure site for seconds to allow absorption of the blood from the pulpal tissue. The pellets will be placed in 1. After the pulpal blood sample is collected, patency of the root canals will be confirmed using stainless steel hand K-files sizes 10 and Working length will be determined using an electronic apex locator then confirmed radiographically to be 1 mm shorter than radiographic apex.

Mechanical preparation will be completed in a crown down technique with ProTaper Next10 rotary files set on an endodontic motor adjusted at a speed of rpm and torque of gcm. In-and-out motions will be applied with stroke lengths not exceeding 3mm in the cervical, middle, and apical thirds until attaining the established WL.

The root canal will be thoroughly irrigated with 3 mL of 2. The canal will then be dried using sterile paper points. Master cone fit radiograph will be taken and then the root canal will be obturated at the same appointment with matching-size gutta percha points and resin-based sealer using cold lateral compaction technique. Access cavity will be sealed with Coltosol F temporary filling material. At the end of the session, each patient will be instructed to complete a pain diary, VAS , at specific intervals; immediately after treatment completion; and 6, 12, 24, and 48 hours after the completion of treatment.

The patient will be asked to mark the level of pain on this cm line. The distance from the left end to the mark made by the patient, which will be measured by the operator with a ruler, is the pain intensity.

Patients will be contacted by their operator at each time-point to check on them and as a reminder. Then, information will be documented. Drug Information available for: Prednisolone Prednisolone acetate Methylprednisolone acetate Methylprednisolone Prednisolone sodium phosphate Potassium bicarbonate Prednisolone phosphate Prednisolone sodium succinate Methylprednisolone sodium succinate Potassium chloride Diclofenac sodium Diclofenac potassium Diclofenac.

FDA Resources. Arms and Interventions. Steroidal anti-inflammatory drug as a preoperative medication. In the first group, each patient was given 25 mg prednisolone intramuscularly immediately after surgery. In the second group, each patient was given 25 mg prednisolone and diclofenac intramuscularly immediately after surgery, and in the third group, each patient was given sterile saline solution as control group. Postoperative pain was evaluated by visual analogue scale on the day of surgery.

Gislason, G. Buettner, C. Ramkumar, S. Moghadam-Kia, S. Bhutia, Y. Damas, J. Paiva, G. Silverstein, F. Sparrow, C. Abbas, S. Osafo, N. Antonopoulos, A. Coutinho, A. Khan, S. McGinnis, S. Greene, E. Close Print this page. Content: Citation Only. Citation and Abstract. Close About this journal.

Related Journals Current Chinese Science. Anti-Cancer Agents in Medicinal Chemistry. Current Chinese Chemistry. Current Bioactive Compounds. Current Drug Discovery Technologies. Current Drug Safety. Current Drug Targets. View More. Advances in Anticancer Agents in Medicinal Chemistry. Advances in Mathematical Chemistry and Applications. Advances in Organic Synthesis. Article Metrics. Journal Information.

Abstract: : Purpose: To evaluate the efficacy of diclofenac sodium 0. Methods: One hundred consecutive eyes scheduled for clear corneal phacoemulsification cataract surgery were prospectively randomized to receive either diclofenac or prednislone for postoperative treatment.

Postoperative discomfort, redness, best-corrected visual acuity BCVAsigns of inflammation and intraocular pressure IOP were assessed at each visit. To assess postoperative discomfort or pain, a visual linear point pain scale was usedon which patients were asked to indicate their discomfort or pain on a scale from 0 no pain to 10 maximum pain. Results: Ninety-eight eyes 98 patients completed the study.

The mean age of the 40 men and 48 women was Diclofenac patients reported significant less postoperative discomfort. Patients on diclofenac resulted in faster wound healing. Conclusions: Diclofenac may be as effective and as safe as prednisolone in controlling postoperative inflammation whitout having the side effects of prednisolone. Purchase this article with an account.

Commercial Relationships A. Voudouri, None; P. Zafirakis, None; G. Livir-Rallatos, None; C. Canakis, None; N. Markomichelakis, None. Alerts User Alerts. You will receive an email whenever this article is corrected, updated, or cited in the literature. You can manage this and all other alerts in My Account. This feature is available to authenticated users only. Get Citation Citation. Get Permissions. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.

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It was determined that the combination of a single dose of prednisolone and diclofenac is well-suited to the treatment of postoperative pain, trismus. The combination of diclofenac and prednisolone has a better analgesic and anti-inflammatory effect. It was determined that the combination of a single dose of prednisolone and diclofenac is well-suited to the treatment of postoperative pain, trismus. The combination of diclofenac and prednisolone is well suited to the treatment of postoperative pain, trismus, and swelling after dental surgical procedures. Objective:To compare diclofenac sodium with prednisolone acetate for the control of postoperative inflammation after cataract surgery. Master cone fit radiograph will be taken and then the root canal will be obturated at the same appointment with matching-size gutta percha points and resin-based sealer using cold lateral compaction technique. Bioequivalence studies and pharmacokinetic properties of atorvastatin 40 mg tablet in healthy Bengali subjects.

Study record managers: refer to the Data Element Definitions if submitting registration or results information. To assess the effect of using diclofenac potassium versus prednisolone as a pre-medication compared to placebo on:. After confirming the diagnosis and making sure that the patient conforms to all eligibility criteria, the principal investigator will enroll the patient in the study.

Intervention Group 2 Prednisolone : single, oral dose of 30 mg prednisolone one and a half tablets Solupred oro 20 mg, ARE, Aventis Intercontinental, Paris, France 30 min before starting endodontic treatment. Control Group Placebo : The patients assigned to this group will be given a placebo tablet Starch, Bridgewater, NJ one hour before starting endodontic treatment. The participants will be blinded to the study hypothesis as to which intervention is expected to be better.

The patients, who already do not know their treatment group, will assess the level of their post-endodontic pain. Resource links provided by the National Library of Medicine MedlinePlus related topics: Potassium Drug Information available for: Prednisolone Prednisolone acetate Methylprednisolone acetate Methylprednisolone Prednisolone sodium phosphate Potassium bicarbonate Prednisolone phosphate Prednisolone sodium succinate Methylprednisolone sodium succinate Potassium chloride Diclofenac sodium Diclofenac potassium Diclofenac U.

Drug: Prednisolone 30 mg Steroidal anti-inflammatory drug as a preoperative medication Other Name: One and a half tablets Solupred oro 20 mg, ARE, Aventis Intercontinental, Paris, France Experimental: Diclofenac potassium premedication Single, oral dose of 50 mg diclofenac potassium pre-medication 1 hour before starting endodontic treatment.

Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

We're building a better ClinicalTrials. Check it out and tell us what you think! Hide glossary Glossary Study record managers: refer to the Data Element Definitions if submitting registration or results information.

Search for terms. Save this study. Warning You have reached the maximum number of saved studies Effect of Diclofenac Potassium Versus Prednisolone on Post-endodontic Pain and Pulpal IL-8 Expression The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.

Listing a study does not mean it has been evaluated by the U. Federal Government. Read our disclaimer for details. Recruitment status was: Not yet recruiting First Posted : October 30, Last Update Posted : October 30, View this study on Beta.

Study Description. To assess the effect of using diclofenac potassium versus prednisolone as a pre-medication compared to placebo on: Intensity of post-endodontic pain in patients with symptomatic irreversible pulpitis. Pulpal IL-8 expression. Incidence of post-endodontic pain in patients with symptomatic irreversible pulpitis.

Show detailed description. Hide detailed description. Detailed Description:. Patients will be asked to rate their pre-operative pain intensity ie, before the commencement of any treatment [baseline score]; on the visual analogue scale "VAS" Enrolled patients will be randomly assigned into one of three groups: Intervention Group 1 Diclofenac Potassium : single, oral dose of 50 mg diclofenac potassium pre-medication Cataflam; NOVARTIS Pharma, Basel, Switzerland one hour before starting endodontic treatment.

After anesthesia is achieved and verified with Endo-Ice, the patient's tooth is isolated with a rubber dam, caries is excavated, and the pulp is exposed with a sterile round bur. Preparation of access cavity using a sterile round carbide bur and an Endo-Z bur Sample Collection: Blood from the exposed surface of the pulp will be collected with 2 sterile cotton pellets.

The pellets will be held at the exposure site for seconds to allow absorption of the blood from the pulpal tissue.

The pellets will be placed in 1. After the pulpal blood sample is collected, patency of the root canals will be confirmed using stainless steel hand K-files sizes 10 and Working length will be determined using an electronic apex locator then confirmed radiographically to be 1 mm shorter than radiographic apex.

Mechanical preparation will be completed in a crown down technique with ProTaper Next10 rotary files set on an endodontic motor adjusted at a speed of rpm and torque of gcm. In-and-out motions will be applied with stroke lengths not exceeding 3mm in the cervical, middle, and apical thirds until attaining the established WL. The root canal will be thoroughly irrigated with 3 mL of 2. The canal will then be dried using sterile paper points.

Master cone fit radiograph will be taken and then the root canal will be obturated at the same appointment with matching-size gutta percha points and resin-based sealer using cold lateral compaction technique. Access cavity will be sealed with Coltosol F temporary filling material. At the end of the session, each patient will be instructed to complete a pain diary, VAS , at specific intervals; immediately after treatment completion; and 6, 12, 24, and 48 hours after the completion of treatment.

The patient will be asked to mark the level of pain on this cm line. The distance from the left end to the mark made by the patient, which will be measured by the operator with a ruler, is the pain intensity. Patients will be contacted by their operator at each time-point to check on them and as a reminder.

Then, information will be documented. Drug Information available for: Prednisolone Prednisolone acetate Methylprednisolone acetate Methylprednisolone Prednisolone sodium phosphate Potassium bicarbonate Prednisolone phosphate Prednisolone sodium succinate Methylprednisolone sodium succinate Potassium chloride Diclofenac sodium Diclofenac potassium Diclofenac. FDA Resources. Arms and Interventions.

Steroidal anti-inflammatory drug as a preoperative medication. Single, oral dose of 50 mg diclofenac potassium pre-medication 1 hour before starting endodontic treatment. Non-steroidal anti-inflammatory drug as a preoperative medication. Placebo tablet 1 hour before starting endodontic treatment.

Outcome Measures. Primary Outcome Measures : Change in the intensity of post-endodontic pain [ Time Frame: Immediately after treatment completion; and at 6, 12, 24, and 48 hours post-operatively ] Pain intensity will be evaluated using visual analogue scale. Other Outcome Measures: Change in the incidence of post-endodontic pain [ Time Frame: Immediately after treatment completion; and at 6, 12, 24, and 48 hours post-operatively ] Pain incidence will be evaluated using visual analogue scale.

Eligibility Criteria. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Inclusion Criteria: Age between years. Males and females. American Society of Anesthesiologists class 1 or 2.

Patients who had not taken any anti-inflammatory drugs the day of the root canal procedure unless they belong to one of the intervention groups. Teeth other than single-rooted teeth. Radiographic evidence of external or internal root resorption vertical root fracture, perforation, or calcification. Immature teeth. Unrestorable teeth or teeth with severe periodontal disease. Patients with a known allergy, sensitivity, or history of other adverse reactions to the medications administered.

Patients with a history of active peptic ulcer within the preceding 12 months, bleeding problems, anticoagulant use within the last month, or kidney disease. Pregnant or nursing females. Patients who are unable to provide informed consent. Contacts and Locations. Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials. More Information. National Library of Medicine U. National Institutes of Health U. Department of Health and Human Services. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Symptomatic Irreversible Pulpitis. Phase 4. Study Type :. Interventional Clinical Trial. Estimated Enrollment :. In this proposed study, the participant, and the assessor will be blinded.

The laboratory technician at the microbiological department will not know the treatment group of the patients. The treatment groups will remain anonymous at the end of the study during assessment by the statistician.

Estimated Study Start Date :. Estimated Primary Completion Date :. Estimated Study Completion Date :. Experimental: Prednisolone premedication Single, oral dose of 30 mg prednisolone pre-medication 30 min before starting endodontic treatment. Experimental: Diclofenac potassium premedication Single, oral dose of 50 mg diclofenac potassium pre-medication 1 hour before starting endodontic treatment.

Placebo Comparator: Placebo Placebo tablet 1 hour before starting endodontic treatment. Drug: Placebo Starch. October 30, Key Record Dates.



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